Jingzhen Yuan, PhD
Jingzhen Yuan, PhD
Acute pancreatitis is a serious medical disorder with no current therapies directed to the molecular pathogenesis of the disorder. Alcohol abuse is one of the major causes. Because of the lack of therapy, there continues to be significant morbidity and mortality from the disease. The research project of Jingzhen Yuan, PhD, is designed to address this deficit by establishing that protein kinase D (PKD) is a molecular signal that mediates several key pathologic pathways in alcohol abuse-induced pancreatitis; and creating small molecule ligands to inhibit PKD. The results will lead to therapies for the disease with the likelihood of significantly decreasing its morbidity and mortality.
- Doctorate: Jiangsu University Zhenjiang Medical College, 1981
- Master's: Nanjing Medical University, 1986
- Residency: First Hospital of Nanjing Medical University, 1991
- Doctorate: Mississippi State University, 1996
- Post Doctorate: UCLA, 2002
Awards & Activities
- R01 award from NIH/NIAAA "Targeting protein kinase D in alcoholic pancreatitis". The goal of this project is to determine whether protein kinase D inhibition is a viable approach for treating alcoholic pancreatitis. Role: PI, 2016-present
- Pilot Project Funding from Southern California Research Center for ALPD and Cirrhosis Research Program to investigate the role of protein kinase D in alcoholic pancreatitis. Role: PI, 2009-10
- The CURE Named New Investigator Award from UCLA CURE: Digestive Disease Research Center to study the regulation and function of protein kinase D3 in mitogenic neuropeptides mediated signaling pathways. Role: PI, 2004-06
- Pilot and Feasibility Study Award from UCLA CURE Center Grant NIH NIDDK to investigate the phosphorylation dependent mechanisms of protein kinase D activation through GI peptide signaling pathways. Role: PI, 2003-04
- NIH/NIDDK National Research Serves Award Postdoctoral Fellowship (F32) from to study protein kinase D regulation by gastrointestinal peptides, 1998-2000
Click here for a list of peer-reviewed publications.
- Yuan J, Tan T, Geng M, Tan G, Chheda C, Pandol SJ. Novel small molecule inhibitors of protein kinase D suppress NF-kappaB activation and attenuate the severity of rat cerulein pancreatitis. Front Physiol. 2017 Dec 7;8:1014.
- Yuan J, Pandol SJ. PKD signaling and pancreatitis. J Gastroenterol. 2016 Jul;51(7):651-659.
- Liu Y, Yuan J, Tan T, Jia W, Lugea A, Mareninova OA, Waldron RT, Pandol SJ. Genetic inhibition of protein kinase Cε attenuates necrosis in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G550-563.