Dan Theodorescu, MD, PhD

PHASE ONE Foundation Distinguished Chair

Director, Cedars-Sinai Cancer

Professor, Surgery

Professor, Pathology and Laboratory Medicine

Dan Theodorescu, MD, PhD

Phone:

310-423-8431

Dan Theodorescu, MD, PhD

PHASE ONE Foundation Distinguished Chair

Director, Cedars-Sinai Cancer

Professor, Surgery

Professor, Pathology and Laboratory Medicine

Dan Theodorescu, MD, PhD, is the director of the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai. From 2010 until 2018, he was director of the University of Colorado Cancer Center and a distinguished university professor. Dr. Theodorescu is known for his work on the molecular mechanisms underlying bladder cancer and tools that determine drug response as well as the discovery of new drugs for cancer. Examples include the discovery of genes that regulate tumor growth and metastasis (RhoGDI2, AGL, GON4L), and novel biomarkers (DNA/NGS, RNA and proteomic) and concepts for precision therapeutic approaches such as the COXEN principle, which is being tested in national (SWOG) clinical trials. He also conceptualized the approach and then led the discovery and development of a "first in class" RalGTPase inhibitor as a new therapeutic in cancer. This drug was awarded a U.S. patent and is in commercial development. His laboratory is funded by grants from the NIH-NCI. Dr. Theodorescu has published over 300 articles including articles in Nature, Science, Cancer Cell, PNAS and JCI.

  • Medical School: Queen's University, Ontario, 1986
  • Internship: University of Toronto, 1987
  • Doctorate: University of Toronto, 1993
  • Residency: University of Toronto, 1994
  • Fellowship: Memorial Sloan-Kettering Cancer Center, 1995
  • Distinguished University Professor, University of Colorado, 2017
  • Hirschler Visiting Professor, University of Washington School of Medicine, 2015
  • Barringer Medal, American Association of Genitourinary Surgeons, 2015
  • Peng Lecture, NYU School of Medicine, 2015
  • Honorary Member Brazilian Cancer Society, 2014

Click here for a list of peer-reviewed publications.

  • Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF. Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol 2006; 7:230-40.
  • Lee JK, Havaleshko DM, Cho H, Weinstein JN, Kaldjian EP, Karpovich J, Grimshaw A, Theodorescu D. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci U S A 2007;104:13086-91.
  • Smith SC, Baras AS, Dancik G, Ru Y, Ding KF, Moskaluk CA, Fradet Y, Lehmann J, Stockle M, Hartmann A, Lee JK, Theodorescu D. A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessment. Lancet Oncol 2011;12:137-43.

English

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