COVID-19 (Coronavirus)

Arun Sharma, PhD

Research Scientist I, Regenerative Medicine Institute, Department of Biomedical Sciences, Smidt Heart Institute

Arun Sharma, PhD

Arun Sharma, PhD

Research Scientist I, Regenerative Medicine Institute, Department of Biomedical Sciences, Smidt Heart Institute

Research in the laboratory of Arun Sharma, PhD, focuses on the applications of human induced pluripotent stem cells (hiPSCs) for modeling cardiovascular diseases in-vitro. The lab utilizes cutting-edge technologies including hiPSCs, CRISPR/Cas9 genome editing, cardiac microfluidic organ-chips, and cardiac organoids in studies aiming to understand the molecular mechanisms driving cardiovascular diseases. For example, the Sharma laboratory employs hiPSC-derived cardiomyocytes (personalized, beating heart muscle cells) to model cardiac viral infections occurring during COVID-19, to examine the developmental mechanisms underlying congenital heart disease, and to understand ways to alleviate the cardiovascular toxicities caused by chemotherapeutic agents. The Sharma lab also has a unique background and interest in space biology, and investigates means by which stem cell biology can intersect with this emerging field.

  • Duke University, BS, Biology, 2012
  • Stanford University, PhD, Stem Cell Biology and Regenerative Medicine, 2016
  • Fellowship: Harvard Medical School, Postdoctoral Fellowship, Cardiovascular Genetics, 2019
  • Fellowship: Cedars-Sinai Medical Center, Postdoctoral Fellowship, Multi-Lineage Disease Modeling, 2021

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