Tyler Mark Pierson, MD, PhD
Assistant Professor, Neurology
Assistant Professor, Pediatrics
Contact Information
Clinical Office
Pediatric Neurology
8723 Alden Dr #240
Los Angeles, CA
90048
Phone:
310-423-4433
Fax:
310-423-1244
Tyler Mark Pierson, MD, PhD
Assistant Professor, Neurology
Assistant Professor, Pediatrics
Specialty
- Peds/Neurology
Subspecialty
- Pediatric Neurology
Research Profile
<p>Dr. Pierson's clinical and research focus is the study of rare neurogenetic disorders with an emphasis on the diagnosis of these disorders in patients of the Pediatric Neurogenetics Clinic. His laboratory research focuses on generating cellular and animal models of these rare disorders with the hope of providing insight into nervous system as a whole and more common CNS disorders.<br /><br />Biomedical research often focuses on common disorders that affect a significant portion of the population (e.g., diabetes, cancer, heart disease). This approach prudently allocates limited research funds toward disorders that have the most widespread effect on collective medical needs. Unfortunately, this path often neglects rare disorders that affect only a handful of patients; however, the study of these rare disorders can be very valuable in providing insight into cellular and molecular functions.</p><p>Rare neurogenetic disorders are often caused by mutations that alter the function of important genes involved in neurodevelopment or function of cells in the nervous system. Many of the genes involved in neurodevelopmental disorders are crucial to cognitive development and human behavior; alternatively, pediatric neurodegenerative disorders occur after normal neurodevelopment with subsequent toxicity occurring due to lack of genes to maintain a functioning nervous system. The Pierson Laboratory studies both of these types of disorders with patient-derived IPSCs, NPCs, inducible-neurons and cerebral organoids to provide insight into neurologic function, as well as researches therapeutic interventions for affected families. </p><p>The recent emergence of genomic methods such as high-density single nucleotide polymorphism arrays, exome sequencing and whole-genome sequencing has revolutionized the ability to make diagnoses of rare or new disorders. Further advances in biotechnology, such as induced pluripotent stem cells, enables researchers to model these disorders with patient-derived cells to confirm the genetic diagnosis and research the mechanisms of disease. This knowledge sets up our ability to generate potential therapeutic interventions for these rare disorders.</p><br /><br />
Education
- Other Degrees: Baylor College of Medicine, 1999
- Medical School: Baylor College of Medicine, 2001
- Residency: Texas Children's Hospital, 2002
- Residency: Hospital of the University of Pennsylvania, 2003
- Fellowship: The Children's Hospital of Philadelphia, 2007
- Fellowship: National Institutes of Health, 2012
Cedars-Sinai Affiliations
- Department of Neurology and Neurosurgery
- Department of Pediatrics
- Pediatric Neurosurgery Program
- Charcot-Tooth-Marie (CMT) Clinic
- Medicine
- Pediatrics
- Regenerative Medicine Institute (Board of Governors Regenerative Medicine Institute)
- Pediatric Neurogenetics
Awards & Activities
- Fashion Industries Guild Endowed Fellowship for the Pediatric Undiagnosed Diseases, 2017
- Fashion Industries Guild Endowed Fellowship in Pediatric Neuromuscular Diseases, 2012
- National Human Genome Research Institute Merit Award
- Member, Child Neurology Society
- Member, American Society of Gene and Cell Therapy
Publications
Click here for a list of peer-reviewed publications.
- C Sheih, N Jones, B Vanle, MG Au, A Huang, APG Silva, H Lee, E Douine, MG Otero, A Choi, K Grand, IP Taff, MR Delgado, MJ Hajianpour, A Seeley, L Rohena, H Vernon, KW Gripp, SA Vergano, S Mohida, S Naidu, AB Sousa, KE Wain, TD Challman, G Beek, D Basel, J Ranells, R Smith, R Yusapov, ML Freckman, L Ohden, L Davis-Keppen, D Chitayat, JJ Dowling, R Finkel, A Dauber, R Spillman, LDM Pena, The Undiagnosed Diseases Network, K Metcalfe, M Splitt, K Lachlan, SA McKee, J Hurst, DR Fitzpatrick, J Morton, H Cox, S Venkate-swaran, JI Young, ED Marsh, S Nelson, J Martinez, JM Graham Jr, U Kini, J Mackay, TM Pierson. GATAD2B-associated neurodevelopmental disorder (GAND): Genetic and clinical insights. Genetics in Medicine 22: 878-888. doi: 10.1038/s41436-019-0747-z.
- TM Pierson, MG Otero, K Grand, A Choi, J Mackay, JI Young, JM Graham Jr, J Mackay. The NuRD Complex and Macrocephaly-associated Neurodevelopmental Disorders. American Journal of Medical Genetics part C 2019 doi: 10.1002/ajmg.c.31752.
- B Johnson, R Kumar, S Oishi, S Alexander, M Sanchez Vega, A Ivancevic, L Pérez-Jurado, A Gardner, D Domingo, E Parnell, S Yoon, J Liebelt, M Lines, H Lefroy, U Kini, Deciphering Developmental Disorders Study, S Grønborg, S Mercier, S Küry, S Bézieau, L Pasquier, M Raynaud, A Afenjar, T Billette de Villemeur, B Keren, J Désir, L Van Maldergem, M Marangoni, N Dikow, M Reijnders, D Koolen, PM VanHasselt, M Weiss, P Zwijnenburg, J Sa, C Falcao Reis, C López-Otín, O Santiago-Fernández, A Fernández-Jaén, A Rauch, K Steindl, P Joset, A Goldstein, S Madan-Khetarpal, E Infante, E Zackai, C Mcdougall, V Narayanan, K Ramsey, S Mercimek-Andrews, L Pena, V Shashi, Undiagnosed Diseases Network, K Schoch, F Pinto e Vairo, PN Pichurin, SA Ewing, SS Barnett, EW Klee, MS Perry, MK Koenig, CE Keegan, JL Schuette, S Asher, Y Perilla-Young, JA Rosenfeld, E Bhoj, P Kaplan, D Li, R Oegema, E van Binsbergen, B van der Zwaag, M Falkenberg Smeland, VShashi, JA Sullivan, I Cutcutache, M Page, M Armstrong, AE Lin, N den Hollander, MJV Hoffer, T Kleefstra, P Penzes, S Wood, T Burne, TM Pierson, M Piper, J Gecz and L Jolly. (2019) Missense variants in USP9X lead to a distinct male neurodevelopmental disorder characterised by a loss of TGFβ signalling. Biological Psychiatry 2019 S0006-3223 (19) 31479-9 doi: 10.1016/j.biopsych.2019.05.028.
Languages Spoken
English / Swedish
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