Maya Koronyo, PhD

Associate Professor, Neurosurgery

Associate Professor, Biomedical Sciences

Research Scientist, Maxine Dunitz Neurosurgical Institute

Maya Koronyo, PhD

Neurosurgery - Pavilion
127 S San Vicente Blvd #A6600
Los AngelesCA
90048

Phone:

310-423-7900

Maya Koronyo, PhD

Associate Professor, Neurosurgery

Associate Professor, Biomedical Sciences

Research Scientist, Maxine Dunitz Neurosurgical Institute

The lack of effective treatment for Alzheimer’s disease (AD) has necessitated more accurate and earlier diagnostic tools as well as disease-modifying therapies. A major focus of the Koronyo-Hamaoui Lab is development of immune-modulation treatment approaches and the investigation of the role that innate immune cells, especially peripheral monocytes and macrophages, may play in CNS repair and regeneration. The team recently discovered that adoptive transfer of bone marrow-derived monocytes to the peripheral blood of symptomatic transgenic AD mice, or immunization with altered myelin-derived antigens, led to marked attenuation of disease progression. This multifaceted immune modulation intervention was found to substantially regulate neuroinflammation, diminish various neuropathologies, and remarkably preserve synapses as well as cognitive function. To enhance capacity of innate immune cells to resist AD pathology, the lab has targeted over-expression of an Aβ degrading enzyme, ACE, to myelomonocytes in murine models of AD. This resulted in substantial prevention of cognitive decline and attenuation of associated pathology. Continued efforts concentrate on identification of novel therapeutic approaches through better understanding of immune mechanisms involved in regulation of detrimental inflammation, clearance of toxic Aβ assemblies, and preservation of synapses by monocytes and macrophages. Another major focus of the Koronyo-Hamaoui Lab has been the pathological change occurring in the retina during AD development as compared to brain pathology. The team has pioneered the identification and characterization of the hallmark pathology of AD, Aβ deposits, in retinas of human patients. These findings have allowed for the development of an innovative method of detecting in vivo retinal amyloid deposits by utilizing curcumin labeling. This noninvasive retinal Aβ plaque imaging has potential applications for earlier AD diagnosis and follow-up response to AD therapies.

View NIH Biographical Sketch as a PDF

  • Undergraduate: Tel-Aviv University, 1995
  • Master's: Tel-Aviv University, 1998
  • Doctorate: Tel-Aviv University, 2005
  • Post Doctorate: Weizmann Institute of Science, 2006
  • Recipient of Collaborative Research Award, DNRCA-CSMC Department of Neurosurgery, 2013-current
  • Alzheimer's Disease Research Award, The BrightFocus Foundation, 2013-current
  • Pioneer in Medicine Award, The Brain Mapping Foundation for Retinal Imaging in Alzheimer's Disease, 2013
  • Recipient of Primary Research Award, Coins for Alzheimer’s Research Trust Fund, 2012-15
  • Expert Panel Speaker, The Association for Research in Vision and Ophthalmology Conference in the Special Interest Group 'Ocular Biomarkers for Early Detection of AD', 2012

Click here for a list of peer-reviewed publications.

  • Shi H, Koronyo Y, Rentsendorj A, Regis GC, Sheyn J, Fuchs DT, Kramerov AA, Ljubimov AV, Dumitrascu OM, Rodriguez AR, Barron E, Hinton DR, Black KL, Miller CA, Mirzaei N, Koronyo-Hamaoui M. Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina. Acta Neuropathologica. 2020.
  • Li, S, Hayden, EY, Garcia, VJ, Fuchs D-T, Sheyn, J, Daley DA, Rentsendorj, A, Torbati, T, Black, KL, Rutishauser, U, Teplow, DB, Koronyo Y, Koronyo-Hamaoui, M. Activated Bone Marrow-derived Macrophages Eradicate Alzheimer’s-Related Aß42 Oligomers and Protect Synapses. Frontiers in Immunology. 2020; 11:49.
  • Koronyo-Hamaoui M, Sheyn J, Hayden EY, Li S, Fuchs DT, Regis GC, Lopes DHJ, Black KL, Bernstein KE, Teplow DB, et al. Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease. Brain. 2019 pii: awz364.

English

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