Wohaib Hasan, PhD, MS

Associate Director, Biobank & Translational Research Core

Assistant Professor, Pathology and Laboratory Medicine

Wohaib Hasan, PhD, MS

Phone:

310-423-0372

Wohaib Hasan, PhD, MS

Associate Director, Biobank & Translational Research Core

Assistant Professor, Pathology and Laboratory Medicine

The research of Wohaib Hasan, PhD, focuses on thrombosis within cardiac chambers in heart failure. Disruptions in blood flow and endothelial function promote thrombus formation within cardiac chambers. Dr. Hasan investigates endothelial anticoagulant pathways, and nerve-endothelial interactions, as potential therapeutic approaches for reducing thrombosis risk. Human tissue from heart failure patients and a transgenic mouse model of dilated cardiomyopathy are used in these studies. The second focus of Dr. Hasan’s studies is on the origins of cardiac arrhythmias in obesity and heart failure. Higher risk of arrhythmias in obese and heart failure subjects may be a consequence of aberrant cardiac neuronal remodeling. Dr. Hasan’s lab focuses on the mechanisms of aberrant cardiac innervation using rodent models and human tissue. In addition to his research program, Dr. Hasan manages the day-to-day operations of the Cedars-Sinai Biobank and Translational Research Core (BTRC). In this capacity, he is intimately involved in guiding the various divisions within the BTRC; tissue procurement and clinical processing (Biobanking), histology and molecular pathology, research instrumentation, and imaging and image analysis.

  • Doctorate: University College London, 1997
  • NIH R01 HL134726-01

Click here for a list of peer-reviewed publications.

  • Tyrrell C, Toyooka A, Khan F, Thornburg KL, Mudd JO, Hasan, W. The neuropeptide galanin promotes an anti-thrombotic phenotype on endocardial endothelial cells from heart failure patients. Auton Neurosci. 2017;206:35-42. [Epub 2017 Jul 12]
  • Schoner A, Tyrrell C, Wu M, Gelow JM, Hayes AA, Lindner JR, Thornburg KL, Hasan W. Endocardial Endothelial Dysfunction Progressively Disrupts Initially Anti then Pro-thrombotic Pathways in Heart Failure Mice. PLoS One. 2015;10(11):e0142940
  • Hasan, W. Autonomic cardiac innervation – Development and adult plasticity (invited review), Organogenesis. 2013 Jul-Sep;9(3):176-93.

English

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