COVID-19 (Coronavirus)

Andrea Dorfleutner, PhD, MS

Associate Professor, Department of Academic Pathology and Department of Biomedical Sciences

Andrea Dorfleutner, PhD, MS

Advanced Health Sciences Pavilion (AHSP)
127 S San Vicente Blvd
# A8105
Los AngelesCA
90048

Phone:

424-315-2397

Advanced Health Sciences Pavilion (AHSP)
127 S San Vicente Blvd
# A8700
Los AngelesCA
90048

Andrea Dorfleutner, PhD, MS

Associate Professor, Department of Academic Pathology and Department of Biomedical Sciences

The research laboratories of Drs. Dorfleutner and Stehlik investigate mechanisms that regulate inflammation, which is a critical part of our innate immune system in response to injury and infections. While acute inflammatory responses have a protective role, immune responses can be detrimental and cause tissue damage and disease if there is dysregulation, excessive release of inflammatory mediators and failure to timely resolve inflammatory responses. Innate immune cells encode several key cytosolic pattern recognition receptors (PRRs) that, upon sensing of a pathogen or danger signal, promote the release of inflammatory cytokines, the activation of NF-?B and the production of type I interferon (IFN). Particularly, production of the potent pro-inflammatory cytokines interleukin (IL)-1b and IL-18 depends on the formation of a large multi-protein complex consisting of a PRR, the adaptor ASC and Caspase-1, called the inflammasome. The inflammasome has been implicated in numerous autoinflammatory and autoimmune diseases, including rheumatic diseases, cardiovascular diseases and metabolic disorders. We aim to understand mechanisms of inflammasome activation and inactivation in health and disease. Thereby we will contribute to a better understanding of inflammatory diseases, which will help to discover future approaches for novel and innovative treatment strategies.

  • Master's: University of Vienna, Austria, 1999
  • Doctorate: University of Vienna, Austria, 2003

English / German

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