David Casero
Acting Associate Professor, Department of Medicine and Biomedical Sciences
Director, Translational Multi'omics, Inflammatory Bowel & Immunobiology Research Institute

Contact Information
Clinical Office
8730 Alden Drive,
Thalians E215
Los Angeles, CA
90048
Phone:
310-423-3853
Fax:
310-423-0224
David Casero
Acting Associate Professor, Department of Medicine and Biomedical Sciences
Director, Translational Multi'omics, Inflammatory Bowel & Immunobiology Research Institute
Research Profile
David Casero, PhD, develops and applies computational methods for the analyses of high-throughput multi-omics data. His lab aims to bridge the gap between traditional approaches where one type of omics data provides a snapshot into potential disease biomarkers and current multi-omics efforts that can provide information into the actual drivers of disease. The Casero Lab is particularly interested on the establishment and maintenance of normal tissue homeostasis, supported by molecular interactions between members of the tissue microenvironment (e.g., epithelial, mesenchymal and immune cells) and additional factors (e.g., signals from microbial cells). A proper understanding of these interactions is instrumental to gain insights into the etiology of some complex diseases like Inflammatory Bowel Disease and cancer.
Education
- B.S.: Complutense University, Spain, 1998
- M.S.: Complutense University, Spain, 2002
- Ph.D.: Complutense University, Spain, 2007
- Post doctorate: UCLA, 2011
Cedars-Sinai Affiliations
- Biomedical Sciences
- Medicine
- Inflammatory Bowel and Immunobiology Research Institute
Awards & Activities
- Associate Editor, BMC Bioinformatics, 2019
- Associate Editor, BMC Systems Biology, 2017
Publications
Click here for a list of peer-reviewed publications.
- Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. Casero D, Sandoval S, Seet CS, Scholes J, Zhu Y, Ha VL, Luong A, Parekh C, Crooks GM. Nat Immunol. 2015 Dec;16(12):1282-1291.
- Organoid-induced differentiation of conventional T cells from human pluripotent stem cells. Montel-Hagen A, Seet CS, Li S, Chick B, Zhu Y, Chang P, Tsai S, Sun V, Lopez S, Chen HC, He C, Chin CJ, Casero D, Crooks GM. Cell Stem Cell. 2019 Mar 7;24(3):376-389.
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK. Microbiome. 2017 Aug 18;5(1):105.
Languages Spoken
English / Spanish