Todd V. Brennan, MD
Cedars-Sinai Comprehensive Transplant Center
8900 Beverly Blvd
Los Angeles, CA
Todd V. Brennan, MD, MS, FACS
- Surgery-General Surgery
- Surgery/Transplant Surgery
Kidney Transplants - Pediatric
The research of Dr. Brennan focuses on how tissue injury causes inflammation and how this inflammation relates to rates of rejection of transplanted organs. Overall, the context in which transplanted organs are encountered by our immune cells is critical to determining the immune response against them. In the setting of tissue injury occurring during organ procurement, storage and transplantation, the immune system is alerted to the presence of tissue damage and initiates a response to this injury. In other words, the immune system recognizes danger signals released by the transplanted organ and can respond aggressively, attacking and damaging the organ. The goal of Dr. Brennan’s research is to identify the molecules that create these signals and develop methods to prevent their release or block their recognition.
- Undergraduate: University of California, Los Angeles, 1994
- Medical School: Harvard Medical School, 1999
- Internship: University of California, San Francisco Medical Center, 2000
- Residency: University of California, San Francisco Medical Center, 2007
- Fellowship: University of California, San Francisco Medical Center, 2009
Awards & Activities
- Clarence Gardner, M.D. Award, 2016
- Health Scholar, Duke University School of Medicine, 2016
- Career Development Award (NIAID), National Institutes of Health, 2012
- Vanguard Award, American Society of Transplant Surgeons, 2010
- Career Development Award in Liver Transplantation, American Association for the Study of Liver Diseases, 2010
Click here for a list of peer-reviewed publications.
- Pollara J, Edwards RW, Lin L, Bendersky VA, Brennan TV. Circulating mitochondria in deceased organ donors are assoicated with immune activation and early graft dysfunction. JCI Insight. 2018;3(15):e121622. https://doi.org/10.1172/jci.insight.121622.
- Barbas AS, Lin L, McRae M, MacDonald AL, Truong T, Yang Y, Brennan TV. Heparan sulfate is a plasma biomarker of acute cellular allograft rejection. PLoS One. 2018 Aug 7;13(8):e0200877. doi: 10.1371/journal.pone.0200877. PMID: 30086133
- Samoylova ML, Nash A, Kuchibhatla M, Barbas AS, Brennan TV. Machine perfusion of donor kidneys may reduce graft rejection. Clin Transplant. 2019 Oct;33(10):e13716. doi: 10.1111/ctr.13716. Epub 2019 Oct 15.PMID: 31541478